Key result
Sciatic nerve stimulation caused greater increases in mean arterial pressure (+32.5 vs +20.2 mmHg) and heart rate (+13.5 vs +8.0 bpm) in spontaneously hypertensive rats versus normotensive rats.
Why the study?
Does sciatic nerve stimulation elicit enhanced cardiovascular responses in spontaneously hypertensive rats compared to normotensive rats?
Population
Anaesthetized spontaneously hypertensive rats (SHR, n=34) and normotensive Wistar-Kyoto (WKY) rats (n=31)
Comparison
Sciatic nerve stimulation before and after… vs Normotensive Wistar-Kyoto rats receiving the…
Design
Preclinical
Authors
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Enhanced somatic pressor responses in hypertensive models; hypothesis-generating for autonomic mechanisms, requires human validation.
Does sciatic nerve stimulation elicit enhanced cardiovascular responses in spontaneously hypertensive rats compared to normotensive rats?
Absolute Event Rate: 32.5% vs 20.2%
Spontaneously hypertensive rats exhibit increased cardiovascular reactivity to somatic stimuli compared to normotensive rats, independent of impaired baroreflex function.
Ruggeri et al. (2000) studied Hypertension (n=65). Sciatic nerve stimulation vs. Normotensive Wistar-Kyoto (WKY) rats was evaluated on Increase in mean arterial pressure (MAP). Sciatic nerve stimulation caused greater increases in mean arterial pressure (+32.5 vs +20.2 mmHg) and heart rate (+13.5 vs +8.0 bpm) in spontaneously hypertensive rats versus normotensive rats.
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