Key result
In spontaneously hypertensive rats, the change in heart rate per change in mean blood pressure was lower, but the change in splanchnic nerve activity was greater compared to normotensive controls.
Population
Conscious, stroke-prone spontaneously hypertensive rats (SHRSP) and normotensive Wistar-Kyoto controls (WKY)
Comparison
Incremental bolus injections of nitroprusside… vs Normotensive Wistar-Kyoto controls (WKY)
Design
Preclinical
Authors
Loading...
Hypothesis-generating for baroreflex impairment in hypertension; human validation required before clinical relevance.
In spontaneously hypertensive rats, sympathetic outflow is more reactive to blood pressure changes while heart rate response is blunted, suggesting impaired autonomic integration.
Unger et al. (1986) studied Hypertension. Incremental bolus injections of nitroprusside and methoxamine vs. Normotensive Wistar-Kyoto controls (WKY) was evaluated on Change in heart rate (HR) and splanchnic nerve activity (SpNA) per change in mean blood pressure (MAP). In spontaneously hypertensive rats, the change in heart rate per change in mean blood pressure was lower, but the change in splanchnic nerve activity was greater compared to normotensive controls.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: