Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 1, 1983AJP Heart and Circulatory Physiology

Autonomic influences on atrioventricular conduction in conscious dogs

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does pharmacologic autonomic blockade alter the maximum pacing rate with 1:1 atrioventricular conduction in conscious dogs?

Population

Normal, conscious resting dogs and dogs that had undergone chronic, intrapericardial cardiac denervation

Comparison

Pharmacologic blockade with atropine or… vs Baseline state without pharmacologic blockade

Design

Preclinical

Authors

JTJ. X. ThomasNorthwestern UniversityWRW. C. RandallLoyola University Chicago

Discussion

Loading...

Member takes

Overview

Does not support clinical extrapolation; leaves open parasympathetic dominance in human AV nodal conduction.

Structured PICO

Does pharmacologic autonomic blockade alter the maximum pacing rate with 1:1 atrioventricular conduction in conscious dogs?

P
Population
Normal, conscious resting dogs and dogs that had undergone chronic, intrapericardial cardiac denervation
I
Intervention
Pharmacologic blockade with atropine (0.2 mg/kg) or propranolol (1.0 mg/kg) combined with right atrial pacing (100-400 beats/min)
C
Comparator
Baseline (control) state without pharmacologic blockade
O
Outcome
Maximum pacing rate with 1:1 atrioventricular conduction (Rmax)surrogate

In conscious resting dogs, the upper limit of AV nodal conduction is primarily determined by parasympathetic rather than sympathetic tone.

Cite This Study

Thomas et al. (1983) studied this question.

synapsesocial.com/papers/6a8bd23abc51310b2bdec91chttps://doi.org/10.1152/ajpheart.1983.244.1.h102
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Beat-by-beat modulation of AV conduction. II. Autonomic neural mechanisms1986 · 42 citations
  2. 2Autonomic control of pacemaker activity in the atrioventricular junction of the dog1978 · 29 citations
  3. 3Integration of heart rate and sympathetic neural effects on AV conduction1988 · 11 citations
  4. 4Chronotropic and dromotropic responses to stimulation of intracardiac sympathetic nerves to sinoatrial or atrioventricular nodal region in anesthetized dogs.1990 · 34 citations
  5. 5Effects of autonomic activity and changes in heart rate on atrioventricular conduction1982 · 45 citations