Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 1, 1978AJP Heart and Circulatory Physiology

Autonomic control of pacemaker activity in the atrioventricular junction of the dog

View Full Paper
Ask AI
Bookmark
Share

Key result

Sympathetic stimulation increases AV junctional rate by ~102% while vagal stimulation drives opposing reductions.

  • n=10

Population

10 open-chest, anesthetized dogs with stable atrioventricular junctional rhythm induced by pentobarbital…

Comparison

Cardiac sympathetic and parasympathetic… vs Baseline/control state and varying levels of…

Design

Preclinical

Authors

DWDon W. WallickCleveland ClinicDFDavid FelderDepartment for Work and PensionsMLMatthew N. LevyTechnion – Israel Institute of Technology

Discussion

Loading...

Member takes

Overview

AV junctional pacemakers respond strongly to autonomic stimuli in dogs; leaves open translation to human arrhythmia care.

Structured PICO

P
Population
10 open-chest, anesthetized dogs with induced AV junctional rhythm used to quantify changes in AV junctional rate during autonomic neural stimulation.
I
Intervention
Cardiac sympathetic and parasympathetic (vagal) stimulation at varying frequencies (e.g., sympathetic at 1.4 Hz, vagal at 8.4 Hz)
C
Comparator
Baseline/control state (0 Hz stimulation) and varying levels of opposing autonomic activity
O
Outcome
Changes in AV junctional ratesurrogate

This preclinical study demonstrates that AV junctional pacemaker cells in dogs are highly responsive to autonomic neural stimulation, with significant but less pronounced vagal-sympathetic interactions compared to SA nodal cells.

Cite This Study

Wallick et al. (1978) studied Induced atrioventricular junctional rhythm (n=10). Cardiac sympathetic and parasympathetic (vagal) stimulation vs. Baseline (control rate of 54 beats/min) was evaluated on Changes in AV junctional rate. Sympathetic stimulation increased the AV junctional rate by 102% from baseline, while vagal stimulation reduced it by 56%, demonstrating significant autonomic interaction.

synapsesocial.com/papers/6aa40524e7e1fc23507494b0https://doi.org/10.1152/ajpheart.1978.235.3.h308
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of repetitive bursts of vagal activity on atrioventricular junctional rate in dogs1979 · 11 citations
  2. 2Effects of autonomic activity and changes in heart rate on atrioventricular conduction1982 · 45 citations
  3. 3Chronotropic and dromotropic responses to stimulation of intracardiac sympathetic nerves to sinoatrial or atrioventricular nodal region in anesthetized dogs.1990 · 34 citations
  4. 4Separate parasympathetic control of heart rate and atrioventricular conduction of dogs1990 · 45 citations
  5. 5Autonomic influences on atrioventricular conduction in conscious dogs1983 · 20 citations