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October 1, 1982AJP Heart and Circulatory Physiology

Effects of autonomic activity and changes in heart rate on atrioventricular conduction

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Why the study?

Does autonomic neural stimulation and changes in atrial pacing frequency alter atrioventricular conduction in anesthetized open-chest dogs?

Population

anesthetized open-chest dogs

Design

Preclinical

Authors

DWDon W. WallickCleveland ClinicPMPaul J. MartinUniversité Paris-SudYMYuta MasudaKyoto Prefectural University

Discussion

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Overview

Rate-dependent autonomic effects on AV conduction shown in dogs; leaves open translation to human electrophysiology.

Structured PICO

Does autonomic neural stimulation and changes in atrial pacing frequency alter atrioventricular conduction in anesthetized open-chest dogs?

P
Population
anesthetized open-chest dogs
I
Intervention
autonomic neural stimulation (vagal and sympathetic) and changes in atrial pacing frequency
O
Outcome
atrioventricular (AV) conduction (AV interval)surrogate

In a canine model, the response of AV conduction to combined sympathetic and vagal stimulation is essentially the algebraic sum of the individual responses.

Cite This Study

Wallick et al. (1982) studied this question.

synapsesocial.com/papers/6a7e7095299be60fdbb29bbdhttps://doi.org/10.1152/ajpheart.1982.243.4.h523
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Integration of heart rate and sympathetic neural effects on AV conduction1988 · 11 citations
  2. 2Sympathetic and periodic vagal influences on antegrade and retrograde conduction through the canine atrioventricular node.1986 · 5 citations
  3. 3Autonomic control of pacemaker activity in the atrioventricular junction of the dog1978 · 29 citations
  4. 4Vagal modulation of the rate-dependent properties of the atrioventricular node.1990 · 36 citations
  5. 5Cardiac electrical responses to vagal stimulation of fibers to discrete cardiac regions1990 · 52 citations