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April 1, 1988AJP Heart and Circulatory Physiology

Integration of heart rate and sympathetic neural effects on AV conduction

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Population

Chloralose-anesthetized autonomically decentralized dogs

Comparison

Sympathetic stimulation and propranolol… vs Computer-driven atrial pacing to reproduce the…

Design

Preclinical

Authors

JLJ. M. LoebInsermJDJ. M. deTarnowskyNorthwestern University

Discussion

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Overview

Sympathetic effects on AV conduction appear rate-dependent in animals; leaves open translation to human arrhythmia management.

Structured PICO

P
Population
Chloralose-anesthetized autonomically decentralized dogs
I
Intervention
Sympathetic stimulation (0.25-2.5 Hz; mean 0.81 Hz) and propranolol (200 micrograms) administration via the sinoatrial node artery
C
Comparator
Computer-driven atrial pacing to reproduce the heart rate associated with control sympathetic stimulation
O
Outcome
Atrioventricular interval (AVI)surrogate

Sympathetic activity restricted to the AV node is less effective in influencing AV conduction than when heart rate changes occur concurrently, indicating a non-linear relationship between heart rate and sympathetic tone on AV conduction.

Cite This Study

Loeb et al. (1988) studied this question.

synapsesocial.com/papers/6a8bd76790fae8fd47e997a7https://doi.org/10.1152/ajpheart.1988.254.4.h651
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of autonomic activity and changes in heart rate on atrioventricular conduction1982 · 45 citations
  2. 2Beat-by-beat modulation of AV conduction. II. Autonomic neural mechanisms1986 · 42 citations
  3. 3Chronotropic and dromotropic responses to stimulation of intracardiac sympathetic nerves to sinoatrial or atrioventricular nodal region in anesthetized dogs.1990 · 34 citations
  4. 4Autonomic influences on atrioventricular conduction in conscious dogs1983 · 20 citations
  5. 5Effects of beta-adrenergic receptor stimulation and blockade on rate-dependent atrioventricular nodal properties.1992 · 24 citations