Key result
Surgical cardiac denervation blunts exercise response and abolishes sensitivity to atropine and propranolol.
Why the study?
The effects of various methods of surgical cardiac denervation on heart action and cardio-circulatory mechanisms were not fully characterized.
Does surgical cardiac denervation alter physiological responses to exercise and autonomic drugs in greyhounds?
Does surgical cardiac denervation alter physiological responses to exercise and autonomic drugs in greyhounds?
Surgical cardiac denervation in a canine model abolishes responses to autonomic drugs and alters exercise hemodynamics.
These canine denervation data should not alter clinical practice; leaves open selective human applicability.
Surgical cardiac denervation was carried out in 25 greyhounds and their responses to exercise, propranolol, and atropine were observed between one and three months afterwards. Our experiments confirm that a denervated heart shows delayed and diminished response to exercise and no response to atropine and propranolol. We found that no cardio-circulatory mechanism seems to be present in the cavae and that hearts can be `selectively9 denervated to produce an isolated increase in right ventricular pressure which is presumably due to severance of inhibitory fibres leading to the right ventricle, so that the augmentory fibres are unopposed.
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Otto et al. (1970) studied this question. Surgical cardiac denervation was evaluated on Responses to exercise, propranolol, and atropine. Surgical cardiac denervation in greyhounds resulted in a delayed and diminished response to exercise and no response to atropine and propranolol.
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