Key result
Selective ventricular denervation in dogs resulted in better tolerance to pacing-induced heart failure and significantly less catecholamine desensitization compared to intact dogs (P<.05).
Why the study?
Does selective ventricular denervation improve hemodynamic parameters and reduce catecholamine desensitization in a canine model of pacing-induced heart failure?
Population
18 dogs chronically instrumented for measurement of left ventricular and arterial pressures, LV dP/dt, LV…
Comparison
Selective ventricular denervation vs Intact dogs (no denervation)
Design
Preclinical
Follow-up
3 to 4 weeks
Authors
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Should not change heart failure management; hypothesis-generating for selective denervation to limit catecholamine desensitization.
Does selective ventricular denervation improve hemodynamic parameters and reduce catecholamine desensitization in a canine model of pacing-induced heart failure?
p-value: p=<.05
Selective ventricular denervation in a canine model attenuates the progression of pacing-induced heart failure and preserves inotropic responsiveness to catecholamines, indicating that intact ventricular innervation is required for physiological catecholamine desensitization.
Sato et al. (1997) studied Heart failure (n=18). Selective ventricular denervation (surgical technique) vs. Intact dogs was evaluated on Changes in LV end-diastolic stress, LV dP/dt, and catecholamine desensitization (p=<.05). Selective ventricular denervation in dogs resulted in better tolerance to pacing-induced heart failure and significantly less catecholamine desensitization compared to intact dogs (P<.05).
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