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September 1, 1972Cardiovascular Research

Left ventricular performance in the conscious dog with chronically denervated heart

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Population

Conscious dogs with chronically denervated hearts and implanted aortic flow and left ventricular pressure…

Comparison

Chronic cardiac denervation vs Dogs with innervated hearts (historical reference)

Design

Preclinical

Authors

MNMark I. M. NobleElectrophysiologyJSJ. StubbsMidhurst Community HospitalDTD TrenchardEast Sussex County Council

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Implication

Denervation abolishes sinus arrhythmia without hemodynamic impairment in dogs; leaves open translation to human physiology.

Structured PICO

P
Population
Conscious dogs with chronically denervated hearts and implanted aortic flow and left ventricular pressure transducers
I
Intervention
Chronic cardiac denervation
C
Comparator
Dogs with innervated hearts (historical reference)
O
Outcome
Left ventricular performance (cardiac output, stroke volume, maximum acceleration of blood, maximum rate of rise of left ventricular pressure)surrogate

Chronic cardiac denervation in dogs abolishes sinus arrhythmia but does not significantly impair baseline left ventricular performance or responses to physiological stressors.

Cite This Study

Noble et al. (1972) studied this question.

synapsesocial.com/papers/6a8654ac54e3ec4cc25aed2bhttps://doi.org/10.1093/cvr/6.5.457
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Time course of left ventricular function after cardiac denervation in conscious dogs.1992 · 4 citations
  2. 2Adverse effects of chronic cardiac denervation in conscious dogs with myocardial ischemia.1985 · 41 citations
  3. 3Initial cardiovascular adjustment to exercise in dogs with chronic cardiac denervation1964 · 70 citations
  4. 4Left Ventricular Residual Volume in the Intact and Denervated Dog Heart1965 · 11 citations
  5. 5Changes in left ventricular dimensions and performance resulting from acute and chronic volume overload in the conscious dog1983 · 14 citations