Why the study?
Does cardiac denervation reduce left ventricular function in conscious dogs?
Population
Conscious dogs (normal and cardiac-denervated)
Comparison
Cardiac denervation vs Normal (N) dogs
Design
Preclinical
Follow-up
8 weeks
Authors
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May impair LV function post-denervation in dogs; leaves open relevance to human transplant or ablation settings.
Does cardiac denervation reduce left ventricular function in conscious dogs?
Cardiac denervation in conscious dogs results in a sustained reduction of left ventricular function over a wide range of ventricular loading conditions.
Paré et al. (1992) studied this question.
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