What question did this study set out to answer?

This research aims to explore how different compounds affect digitalis-induced arrhythmias and electrical shock sensitivity in dogs.

January 1, 1969CirculationOpen Access

Cardioversion and Digitalis

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Why the study?

Do propranolol, dextro-propranolol, and ICI50,172 reduce digitalis-induced arrhythmias and sensitization to electrical shock in anesthetized dogs?

Population

Anesthetized dogs with digitalis-induced arrhythmias and digitalis-induced sensitization to electrical shock

Design

Preclinical

Authors

SWStephen M. WittenbergUniversity of Bern BLBernard LownElectrophysiology

Discussion

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Implication

Beta-blockade may precipitate VT in digitalis toxicity; leaves open whether nonspecific effects warrant study in humans.

Key Points

This research aims to explore how different compounds affect digitalis-induced arrhythmias and electrical shock sensitivity in dogs.
Experiments conducted on anesthetized dogs.
Propranolol, dextro-propranolol, and ICI50,172 were administered at varying doses to assess their effects.
Heart rate and arrhythmia control were monitored during interventions.
Propranolol in beta-blocking doses did not reduce ouabain-induced ventricular tachycardia or shock sensitivity.
Higher doses of propranolol abolished both arrhythmia and shock sensitivity after initial control.
Dextro-propranolol successfully abolished shock sensitivity, while ICI50,172 did not affect it.

Structured PICO

Do propranolol, dextro-propranolol, and ICI50,172 reduce digitalis-induced arrhythmias and sensitization to electrical shock in anesthetized dogs?

Population

Anesthetized dogs with digitalis-induced arrhythmias and digitalis-induced sensitization to electrical shock

Intervention

Propranolol, dextro-propranolol, and ICI50,172

Outcome

Ouabain-induced ventricular tachycardia (VT) and sensitization to electrical shocksurrogate

In a canine model, the efficacy of propranolol against digitalis-induced arrhythmias and shock sensitization is mediated by its nonspecific antiarrhythmic properties rather than beta-blockade.

Cite This Study

Wittenberg et al. (1969) studied this question.

synapsesocial.com/papers/6a716522febe604dd70a10af https://doi.org/10.1161/01.cir.39.1.29

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Cardioversion and Digitalis

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Cardioversion and Digitalis

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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