Why the study?
Does intravenous propranolol reduce arrhythmias following acute coronary artery occlusion in dogs?
Population
Conscious dogs with acute ligation of a branch of the left coronary artery
Design
Preclinical
Follow-up
4 days
Authors
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IV propranolol spares early post-ligation arrhythmias yet attenuates adrenaline-driven ectopy in canine subacute infarction; leaves open beta-blockade timing for human arrhythmia prevention.
Does intravenous propranolol reduce arrhythmias following acute coronary artery occlusion in dogs?
In a canine model of acute coronary occlusion, intravenous propranolol reduces adrenaline-induced ectopic arrhythmias in the subacute phase via beta-receptor blockade.
Shanks et al. (1967) studied this question.
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