September 1, 1968British Journal of PharmacologyOpen Access

The biological properties of the optical isomers of propranolol and their effects on cardiac arrhythmias

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Why the study?

Do the optical isomers of propranolol differ in their beta-blocking and antiarrhythmic activities in animal models?

Population

Animal models including dogs, guinea-pigs, frogs, and cats.

Comparison

(+)-propranolol and (-)-propranolol vs Compared against each other and the racemic…

Design

Preclinical

Authors

ABA. M. BarrettCork University Hospital VCVALERIE A. CULLUMUniversity of Hertfordshire

Discussion

Member takes

Overview

Distinguishes beta-blockade from membrane effects in animal arrhythmia models; leaves open clinical translation of propranolol isomers.

Structured PICO

Do the optical isomers of propranolol differ in their beta-blocking and antiarrhythmic activities in animal models?

Population

Animal models including dogs, guinea-pigs (isolated atrial muscle), frogs (isolated nerve preparation), and cats (anaesthetized with halothane).

Intervention

(+)-propranolol and (-)-propranolol

Comparator

Compared against each other and the racemic compound

Outcome

Beta-blocking potency (response to isoprenaline) and antiarrhythmic activity (prevention of adrenaline-induced arrhythmias and reversal of ouabain-induced ventricular tachycardia)surrogate

Both (+)- and (-)-propranolol exhibit antiarrhythmic properties, but (-)-propranolol is significantly more potent as a beta-blocker and requires lower doses for antiarrhythmic effects.

Cite This Study

Barrett et al. (1968) studied this question.

synapsesocial.com/papers/6a86630780e29fc8e54ca8dd https://doi.org/10.1111/j.1476-5381.1968.tb07949.x

View Full Paper

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September 1, 1968British Journal of PharmacologyOpen Access

The biological properties of the optical isomers of propranolol and their effects on cardiac arrhythmias

View Full Paper

Ask AI

Bookmark

Why the study?

Do the optical isomers of propranolol differ in their beta-blocking and antiarrhythmic activities in animal models?

Population

Animal models including dogs, guinea-pigs, frogs, and cats.

Comparison

(+)-propranolol and (-)-propranolol vs Compared against each other and the racemic…

Design

Preclinical

Authors

ABA. M. BarrettCork University Hospital VCVALERIE A. CULLUMUniversity of Hertfordshire

Discussion

Member takes

Overview

Distinguishes beta-blockade from membrane effects in animal arrhythmia models; leaves open clinical translation of propranolol isomers.

Structured PICO

Do the optical isomers of propranolol differ in their beta-blocking and antiarrhythmic activities in animal models?

Population

Animal models including dogs, guinea-pigs (isolated atrial muscle), frogs (isolated nerve preparation), and cats (anaesthetized with halothane).

Intervention

(+)-propranolol and (-)-propranolol

Comparator

Compared against each other and the racemic compound

Outcome

Beta-blocking potency (response to isoprenaline) and antiarrhythmic activity (prevention of adrenaline-induced arrhythmias and reversal of ouabain-induced ventricular tachycardia)surrogate

Both (+)- and (-)-propranolol exhibit antiarrhythmic properties, but (-)-propranolol is significantly more potent as a beta-blocker and requires lower doses for antiarrhythmic effects.

Cite This Study

Barrett et al. (1968) studied this question.

synapsesocial.com/papers/6a86630780e29fc8e54ca8dd https://doi.org/10.1111/j.1476-5381.1968.tb07949.x

Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

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