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June 1, 1969British Journal of PharmacologyOpen Access

The relevance of β‐receptor blockade to ouabain‐induced cardiac arrhythmias

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Population

Preclinical models: intact and desheathed frog sciatic nerve, guinea-pigs, and isolated rabbit atria

Comparison

-propranolol,-propranolol,-propranolol, and… vs Comparisons between different isomers and agents

Design

Preclinical

Authors

ADA N DohadwallaIndian Institute of Technology BombayAFA. STONE FREEDBERGHarvard UniversityEWE. M. Vaughan WilliamsHaffkine Institute

Discussion

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Implication

Associates antiarrhythmic efficacy with beta-blockade in this model; hypothesis-generating and should not change clinical practice.

Structured PICO

P
Population
Preclinical models: intact and desheathed frog sciatic nerve, guinea-pigs, and isolated rabbit atria
I
Intervention
(+)-propranolol, (+/-)-propranolol, (-)-propranolol, and I.C.I. 50172
C
Comparator
Comparisons between different isomers and agents
O
Outcome
Local anaesthetic potency, protection against ouabain-induced ventricular fibrillation, and rate of rise of intracellularly recorded action potentialsurrogate

This preclinical study demonstrates that the antiarrhythmic effect of propranolol against ouabain-induced ventricular fibrillation is strongly associated with its beta-blocking activity rather than its local anesthetic properties.

Cite This Study

Dohadwalla et al. (1969) studied this question.

synapsesocial.com/papers/6a73dae014e943abc869f625https://doi.org/10.1111/j.1476-5381.1969.tb09503.x
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1THE ANTIARRHYTHMIC ACTIONS OF BETA ADRENERGIC BLOCKING AGENTS1965 · 72 citations
  2. 2VAGAL AND SYMPATHETIC EFFECTS ON THE PACEMAKER FIBERS IN THE SINUS VENOSUS OF THE HEART1956 · 363 citations
  3. 3Beta-adrenergic Receptor Blockade in Cardiac Arrhythmias1963 · 168 citations
  4. 4THE MODE OF ACTION OF QUINIDINE ON ISOLATED RABBIT ATRIA INTERPRETED FROM INTRACELLULAR POTENTIAL RECORDS1958 · 124 citations