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October 1, 1969British Journal of PharmacologyOpen Access

A comparison of the anti‐arrhythmic actions of I.C.I. 50172 and (—)‐propranolol and their effects on intracellular cardiac action potentials and other features of cardiac function

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Population

In vitro cardiac cells and anaesthetized guinea-pigs

Comparison

I.C.I. 50172 vs (-)-propranolol

Design

Preclinical

Authors

JPJulius Gy. PappElectrophysiologyEWE. M. Vaughan WilliamsHaffkine Institute

Discussion

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Implication

May indicate antiarrhythmic effects independent of local anaesthesia in animals; leaves open translation to human arrhythmias.

Structured PICO

P
Population
In vitro cardiac cells and anaesthetized guinea-pigs
I
Intervention
I.C.I. 50172
C
Comparator
(-)-propranolol
O
Outcome
Effects on intracellular cardiac action potentials and protection against ouabain-induced ventricular fibrillationsurrogate

I.C.I. 50172 demonstrates anti-arrhythmic properties in vivo that are disproportionately higher than its in vitro local anaesthetic and beta-blocking activities compared to propranolol.

Cite This Study

Papp et al. (1969) studied this question.

synapsesocial.com/papers/6a73dae014e943abc869f624https://doi.org/10.1111/j.1476-5381.1969.tb10576.x
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinical Use of I.C.I. 50172 as an Antidysrhythmic Agent in Heart Failure1968 · 38 citations
  2. 2Adrenaline: Mechanism of Action on the Pacemaker Potential in Cardiac Purkinje Fibers1968 · 216 citations
  3. 3The effects of some β‐adrenoreceptor blocking drugs on the uptake and release of noradrenaline by the heart1968 · 67 citations