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July 1, 1966Canadian Journal of Physiology and Pharmacology

Propranolol (Inderal) in Experimentally-Induced Cardiac Arrhythmias

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Why the study?

Does propranolol prevent or reverse experimentally induced cardiac arrhythmias in animal models?

Population

Animal models with experimentally induced cardiac arrhythmias

Design

Preclinical

Authors

BLBenedict R. LucchesiElectrophysiologyLWLeighton S. WhitsittUniversity of MichiganNBNeil L. BrownCummins (United Kingdom)

Discussion

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Overview

Should not change clinical practice; leaves open translation of canine antiarrhythmic effects to humans.

Structured PICO

Does propranolol prevent or reverse experimentally induced cardiac arrhythmias in animal models?

P
Population
Animal models (including anesthetized dogs) with experimentally induced cardiac arrhythmias (methylchloroform-adrenaline, U-0882-isoproterenol, and ouabain intoxication)
I
Intervention
Propranolol administered at a dose sufficient to produce beta adrenergic receptor blockade
O
Outcome
Prevention of cardiac arrhythmias and reversal of ventricular tachycardiasurrogate

Propranolol demonstrates potent antiarrhythmic activity in preclinical models, preventing sympathomimetic-induced arrhythmias and reversing ouabain-induced ventricular tachycardia.

Cite This Study

Lucchesi et al. (1966) studied this question.

synapsesocial.com/papers/6a84268ca47fb2e1cdb29810https://doi.org/10.1139/y66-069
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Acute and Chronic Effects of an Adrenergic Beta-Receptor Blocking Agent (Propranolol) in Treatment of Cardiac Arrhythmias1966 · 38 citations
  2. 2The biological properties of the optical isomers of propranolol and their effects on cardiac arrhythmias1968 · 564 citations
  3. 3USE OF A BETA ADRENERGIC RECEPTOR BLOCKING AGENT (PROPRANOLOL) IN THE TREATMENT OF CARDIAC ARRHYTHMIAS1968 · 1 citations
  4. 4Clinical experiences with propranolol1965 · 82 citations
  5. 5Effect of Propranolol on Paroxysmal Ventricular Fibrillation1966 · 8 citations