Why the study?
Does isoproterenol or propranolol alter pharmacologically induced depression of intraventricular conduction in dogs?
Population
Anaesthetized, closed-chest dogs with intraventricular conduction depression induced by cibenzoline IV
Comparison
Isoproterenol IV infusion or propranolol IV… vs Depressed conduction state induced by…
Design
Preclinical
Authors
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Adrenergic modulation of cibenzoline-induced conduction slowing in dogs leaves open relevance to human antiarrhythmic therapy.
Does isoproterenol or propranolol alter pharmacologically induced depression of intraventricular conduction in dogs?
In a canine model, depressed intraventricular conduction is sensitive to adrenergic drugs, with isoproterenol improving and propranolol worsening conduction impairment.
Lang et al. (1989) studied this question.
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