December 1, 1969CirculationOpen Access

The Effects of Propranolol on Cardiac Conduction

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Why the study?

Does intravenous propranolol affect atrioventricular and intraventricular conduction?

Population

8 human patients and 6 dogs

Authors

WBWalter D. BerkowitzUnited States Public Health Service AWAndrew L. WitElectrophysiology SLSun H. LauNational Institutes of Health

Discussion

Member takes

Implication

May guide beta-blocker selection for AV slowing without His-Purkinje effects; leaves open randomized outcome data in arrhythmia patients.

Structured PICO

Does intravenous propranolol affect atrioventricular and intraventricular conduction?

Population

8 human patients and 6 dogs (4 normal, 2 with prolonged H-S intervals secondary to toxic doses of digitalis and procainamide)

Intervention

Propranolol 0.1 mg/kg intravenously in patients, and 4 mg/kg intravenously in dogs

Outcome

Atrioventricular (A-V) conduction measured by P-H interval and intraventricular (IV) conduction measured by H-S intervalsurrogate

Intravenous propranolol prolongs atrioventricular conduction without affecting intraventricular conduction, consistent with its beta-adrenergic blocking properties.

Cite This Study

Berkowitz et al. (1969) studied this question.

synapsesocial.com/papers/69d56b6d75589c71d767ca8c https://doi.org/10.1161/01.cir.40.6.855

View Full Paper

Ask AI

Bookmark

The Effects of Propranolol on Cardiac Conduction

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The Effects of Propranolol on Cardiac Conduction

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider