Why the study?
Do adrenergic beta-blockers and membrane stabilizing agents reduce ouabain-induced cardiac arrhythmias in anaesthetized guinea pigs?
Do adrenergic beta-blockers and membrane stabilizing agents reduce ouabain-induced cardiac arrhythmias in anaesthetized guinea pigs?
In guinea pigs, the antiarrhythmic effects of beta-blockers against ouabain toxicity are mediated by beta-blockade rather than membrane stabilization.
Informs beta-blocker mechanism studies in animal models; leaves open relevance to clinical antiarrhythmic strategies.
The antiarrhythmic effects of dl'propranolol, d-propranolol, metoprolol and lidocaine against ouabain-induced cardiac arrhythmias were studied. It was found that contrary to earlier findings in the dog, the effects of the adrenergic beta-blockers against ouabain-arrhythmias in guinea pigs were due to beta-blocking activity and not the membrane-stabilizing activity of the compounds. The cardioselective beta-blocker, metoprolol, was more or equally effective as dl-propranolol against ouabain-induced arrhythmias in guinea pigs.
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Åberg et al. (1979) studied this question.
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