Why the study?
Do non-steroidal anti-inflammatory drugs protect against ouabain-induced arrhythmias in guinea-pigs?
Do non-steroidal anti-inflammatory drugs protect against ouabain-induced arrhythmias in guinea-pigs?
Aspirin and indomethacin protect against ouabain-induced arrhythmias in a guinea-pig model, potentially through the inhibition of thromboxane A2 synthesis.
Does not support NSAID use for arrhythmias in patients; leaves open differential COX effects in arrhythmia models.
Effects of some non-steroidal anti-inflammatory drugs on ouabain-induced arrhythmias in guinea-pigs were studied. 2. Ventricular premature beats, ventricular fibrillation and cardiac arrest were induced in pentobarbitone-anaesthetized guinea-pigs by a slow intravenous infusion of ouabain. 3. Aspirin and indomethacin were found to accord a significant protection to the guinea-pigs against arrhythmias whereas ketoprofen was found to be ineffective. 4. It is concluded that the protective effect of aspirin and indomethacin may be due to inhibition of synthesis and release of thromboxane A2 from the myocardium.
No takes yet. Share an insight, caveat, or question.
Tripathi et al. (1988) studied this question.