Key result
Ouabain produced both reflex inhibition and stimulation of spontaneous activity in sympathetic nerves to the cat heart, with the stimulation correlated with arrhythmias and antagonized by propranolol.
Population
Cat heart model (preganglionic sympathetic nerves)
Design
Preclinical
Authors
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Experimental ouabain effects on sympathetic activity may drive arrhythmias; leaves open clinical relevance of propranolol counteraction.
In a feline model, ouabain-induced stimulation of cardiac sympathetic nerve activity correlates with arrhythmias and is antagonized by propranolol.
Richard A. Gillis (1969) studied this question. Ouabain and propranolol was evaluated on Spontaneous activity in the preganglionic sympathetic nerves. Ouabain produced both reflex inhibition and stimulation of spontaneous activity in sympathetic nerves to the cat heart, with the stimulation correlated with arrhythmias and antagonized by propranolol.
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