Population
Isolated papillary muscles obtained from normal cat hearts, from chronic, totally cardiac-denervated…
Comparison
Strophanthidin (1.0 µg/ml) added to the bath vs Comparison between normal, denervated, and…
Design
Preclinical
Authors
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Digitalis inotropy persists without norepinephrine stores or innervation in animal muscle; leaves open reserpine interference mechanisms for clinical translation.
Cardiac norepinephrine stores and neural integrity are not essential for the positive inotropic effect of digitalis (strophanthidin), but reserpine treatment interferes with this response through a different mechanism.
Spann et al. (1966) studied this question.
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