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September 1, 1989Journal of Hypertension

Adrenaline infusion in man increases muscle sympathetic nerve activity and noradrenaline overflow to plasma

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Why the study?

Does adrenaline infusion increase muscle sympathetic nerve activity and noradrenaline overflow in healthy young men?

Population

10 healthy young men

Design

Other

Authors

BPBengt PerssonKarolinska University HospitalOAOve K. AnderssonUniversity of North Carolina at Chapel HillPHPaul HjemdahlPreventive Cardiology

Discussion

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Overview

May augment sympathetic activity at physiological adrenaline levels; hypothesis-generating for stress responses, requiring validation in patients.

Structured PICO

Does adrenaline infusion increase muscle sympathetic nerve activity and noradrenaline overflow in healthy young men?

P
Population
10 healthy young men
I
Intervention
Step-wise infusions of adrenaline (0.05-0.6 nmol/kg per min)
O
Outcome
Intra-arterial blood pressure, heart rate, central venous pressure (CVP), efferent muscle sympathetic nerve activity (MSA), arterial and femoral venous plasma concentrations of noradrenaline, and spillover of noradrenalinesurrogate

Physiological stress levels of adrenaline enhance sympathetic nerve activity and noradrenaline release, modulating hemodynamic and neural responses.

Cite This Study

Persson et al. (1989) studied this question.

synapsesocial.com/papers/6a734ede5cfb214a75b86ee3https://doi.org/10.1097/00004872-198909000-00009
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1INCREASED PLASMA NORADRENALINE DURING LOW DOSE ADRENALINE INFUSION IN RESTING MAN AND DURING SYMPATHETIC STIMULATION1985 · 25 citations
  2. 2Human Muscle Sympathetic Activity and Cardiac Catecholamine Spillover: No Support for Augmented Sympathetic Noradrenaline Release by Adrenaline Co-Transmission1998 · 17 citations
  3. 3Circulating adrenaline and blood pressure: the metabolic effects and kinetics of infused adrenaline in man1980 · 51 citations
  4. 4Stress Levels of Adrenaline Amplify the Blood Pressure Response to Sympathetic Stimulation1986 · 38 citations
  5. 5RESPONSE OF ATRIAL NATRIURETIC PEPTIDE TO ADRENALINE AND NORADRENALINE INFUSION IN MAN1988 · 9 citations