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April 1, 1988Clinical and Experimental Pharmacology and Physiology

Response of Atrial Natriuretic Peptide to Adrenaline and Noradrenaline Infusion in Man

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Key result

Adrenaline and noradrenaline infusions significantly increased atrial natriuretic peptide levels in both normal subjects and patients with essential hypertension.

Why the study?

Do adrenaline and noradrenaline infusions affect atrial natriuretic peptide levels in normal subjects and patients with essential hypertension?

Population

Normal subjects and patients with essential hypertension

Design

Other

Authors

TTTerry J. TunnyThe University of QueenslandABAnthony W. BachmannThe University of QueenslandRGRichard D. GordonGeneral Motors (United States)

Discussion

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Overview

May link sympathetic activity to ANP release; hypothesis-generating and should not yet change practice.

Key Points

  • To evaluate the response of atrial natriuretic peptide to adrenaline and noradrenaline infusions in humans.
  • Infusions of adrenaline and noradrenaline were administered to normal subjects and patients with essential hypertension.
  • Circulating levels of adrenaline, noradrenaline, mean arterial pressure, and heart rate were monitored during the infusions.
  • ANP levels significantly increased during both adrenaline and noradrenaline infusions.
  • During adrenaline infusion, circulating adrenaline and noradrenaline levels rose without changes in mean arterial pressure or heart rate.
  • During noradrenaline infusion, circulating noradrenaline levels increased, along with mean arterial pressure, while heart rate and plasma adrenaline levels remained stable.

Structured PICO

Do adrenaline and noradrenaline infusions affect atrial natriuretic peptide levels in normal subjects and patients with essential hypertension?

P
Population
Normal subjects and patients with essential hypertension undergoing adrenaline and noradrenaline infusions.
I
Intervention
Adrenaline and noradrenaline infusions in the physiological range
O
Outcome
Atrial natriuretic peptide (ANP) levelssurrogate

Adrenaline and noradrenaline infusions increase ANP levels, suggesting sympathetic nervous system activity may regulate ANP release via adrenoceptor stimulation.

Cite This Study

Tunny et al. (1988) studied Essential hypertension and normal subjects. Adrenaline and noradrenaline infusion was evaluated on Atrial natriuretic peptide (ANP) levels. Adrenaline and noradrenaline infusions significantly increased atrial natriuretic peptide levels in both normal subjects and patients with essential hypertension.

synapsesocial.com/papers/6a33033758530ca2eee121fehttps://doi.org/10.1111/j.1440-1681.1988.tb01077.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Depressor Effects and Release of Atrial Natriuretic Peptide during Norepinephrine or Angiotensin II Infusion in Man*1986 · 92 citations
  2. 2Release and regulation of atrial natriuretic peptide (ANP)1987 · 85 citations
  3. 3The vasodilator potency of atrial natriuretic peptide in man.1987 · 104 citations
  4. 4Application of a Radioimmunoassay for Angiotensin I to the Physiologic Measurements of Plasma Renin Activity in Normal Human Subjects11969 · 2,239 citations
  5. 5Effects of pacing-induced ischemia on early left ventricular filling and regional myocardial dynamics and their modification by nifedipine.1987 · 26 citations