Key result
Noradrenaline and angiotensin II infusions positively correlate with changes in BP, circulating noradrenaline, and ANP.
Why the study?
The relationship between angiotensin, noradrenaline, and atrial natriuretic peptide levels in humans and their role in blood pressure regulation was unclear.
Do noradrenaline and angiotensin II infusions alter atrial natriuretic peptide levels in humans?
Do noradrenaline and angiotensin II infusions alter atrial natriuretic peptide levels in humans?
Changes in atrial natriuretic peptide levels correlate with changes in noradrenaline and blood pressure, suggesting a role in blood pressure regulation.
No immediate practice change; extends correlative evidence on ANP responses but leaves causal and clinical implications open.
A significant positive correlation was found between changes in circulating noradrenaline (NA) levels and changes in atrial natriuretic peptide (ANP) levels during NA infusion and clonidine administration. 2. A significant positive correlation was also found between changes in arterial blood pressure and changes in ANP level during infusion of angiotensin II and of NA. 3. Two patients with very high circulating NA levels due to phaeochromocytoma, but receiving alpha- and beta-blockade, did not have clearly elevated ANP. A third not receiving medications and aged 73 years had elevated levels. 4. Atrial natriuretic peptide response to NA and angiotensin II may be mediated by changes in blood pressure levels or increased noradrenergic and angiotensinergic receptor activity in the atria or both. Atrial natriuretic peptide may have a role in blood pressure regulation in both normotensive and hypertensive man.
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Tunny et al. (1987) studied Normotension, hypertension, and phaeochromocytoma. Noradrenaline and angiotensin II infusion was evaluated on Changes in atrial natriuretic peptide (ANP) levels. Infusion of noradrenaline and angiotensin II demonstrated significant positive correlations between changes in arterial blood pressure, circulating noradrenaline, and atrial natriuretic peptide levels.
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