January 1, 1988Nephrology Dialysis Transplantation

Increased Plasma Levels of Atrial Natriuretic Peptide in Patients with Chronic Renal Failure: Effect of Noradrenaline Infusion

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Why the study?

Does noradrenaline infusion stimulate atrial natriuretic peptide release in patients with chronic renal failure?

Population

Patients with chronic renal failure before requirement of dialysis, patients on chronic dialysis, and…

Comparison

Noradrenaline infusion and angiotensin II… vs Baseline levels and healthy control subjects.

Design

Other

Authors

BJBente JespersenUniversity Medical Center Groningen EPE PedersenOdense University Hospital

Discussion

Member takes

Implication

Blunted ANP response to noradrenaline in dialysis patients suggests altered regulation; leaves open its contribution to volume overload in ESRD.

Structured PICO

Does noradrenaline infusion stimulate atrial natriuretic peptide release in patients with chronic renal failure?

Population

Patients with chronic renal failure before requirement of dialysis (n=11 in Study 1, n=8 in Study 2), patients on chronic dialysis (n=13 in Study 1, n=12 in Study 2), and healthy control subjects (n=28 in Study 1, n=17 in Study 2, n=14 in Study 3).

Intervention

Noradrenaline infusion (Study 2) and angiotensin II infusion (Study 3).

Comparator

Baseline levels (pre-infusion) and healthy control subjects.

Outcome

Plasma atrial natriuretic peptide (ANP) levels.surrogate

Plasma ANP is elevated in chronic renal failure, and its release is stimulated by noradrenaline in pre-dialysis patients and healthy controls, but this response is blunted in patients on maintenance dialysis.

Cite This Study

Jespersen et al. (1988) studied this question.

synapsesocial.com/papers/6a9909941c4dac29babd4e8f https://doi.org/10.1093/oxfordjournals.ndt.a091751

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Implication

Blunted ANP response to noradrenaline in dialysis patients suggests altered regulation; leaves open its contribution to volume overload in ESRD.

Increased Plasma Levels of Atrial Natriuretic Peptide in Patients with Chronic Renal Failure: Effect of Noradrenaline Infusion

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Increased Plasma Levels of Atrial Natriuretic Peptide in Patients with Chronic Renal Failure: Effect of Noradrenaline Infusion

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider