Why the study?
Does ACE inhibition with enalapril improve the blunted natriuretic and diuretic response to hANP in patients with congestive heart failure?
Population
10 patients with congestive heart failure (CHF) and 10 control subjects of similar age and sex (total n=20).
Comparison
Intravenous infusion of 1-28 human atrial… vs Control subjects receiving the same hANP…
Design
Other
Follow-up
30 minutes (infusion duration)
Authors
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ACE inhibition fails to restore hANP natriuresis in CHF; leaves open non-RAS mechanisms of renal resistance.
Does ACE inhibition with enalapril improve the blunted natriuretic and diuretic response to hANP in patients with congestive heart failure?
Patients with congestive heart failure exhibit renal resistance to atrial natriuretic peptide that is not reversed by ACE inhibition, suggesting mechanisms other than the renin-angiotensin system mediate this resistance.
Wambach et al. (2008) studied this question.
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