Atrial Natriuretic Peptide Levels in Congestive Heart Failure in Man Before and During Converting Enzyme Inhibition
Why the study?
Does the addition of ramipril reduce plasma atrial natriuretic peptide levels in patients with congestive heart failure?
Population
n=7 patients with congestive heart failure on maintenance digoxin and diuretic treatment
Comparison
Ramipril added to maintenance digoxin and… vs Baseline (before addition of ramipril)
Design
Case_series
Authors
Discussion
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Member takes
Implication
May link ramipril hemodynamic effects to falling ANP in heart failure; hypothesis-generating for ANP as biomarker, needs prospective confirmation.
Structured PICO
Does the addition of ramipril reduce plasma atrial natriuretic peptide levels in patients with congestive heart failure?
P
Population
n=7 patients with congestive heart failure (NYHA Functional Class III-IV) on maintenance digoxin and diuretic treatment
I
Intervention
Ramipril added to maintenance digoxin and diuretic treatment
C
Comparator
Baseline (before addition of ramipril)
O
Outcome
Plasma atrial natriuretic peptide (ANP) levelssurrogate
Improvement in haemodynamic function during ACE inhibitor treatment in heart failure is associated with a decline in elevated ANP levels.
Cite This Study
Crozier et al. (1989) studied this question.