Why the study?
Does infusion of atrial natriuretic peptide (99-126) alter renal hemodynamics, sodium excretion, and blood pressure in subjects with chronic renal failure?
Population
Subjects with chronic renal failure (creatinine clearance < 30 ml/min per 1.73 m2)
Design
Other
Authors
Loading...
ANP effects in chronic renal failure are hypothesis-generating; larger trials needed before considering therapeutic use.
Does infusion of atrial natriuretic peptide (99-126) alter renal hemodynamics, sodium excretion, and blood pressure in subjects with chronic renal failure?
Infusion of atrial natriuretic peptide in patients with severe chronic renal failure significantly improves renal hemodynamics and sodium excretion while lowering blood pressure, suggesting a physiological role in volume and pressure regulation.
Swainson et al. (1991) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: