Why the study?
Does human ANF-(99-126) infusion improve diuresis and electrolyte excretion in patients with mild to moderate chronic renal failure?
Population
13 patients with mild to moderate chronic renal failure (12 hypertensive).
Comparison
Human ANF- infusion for 45 minutes at 0.034… vs Healthy control subjects and baseline conditions.
Design
Other
Follow-up
90 minutes
Authors
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May support ANF as a diuretic target in renal failure; leaves open clinical adoption pending randomized trials.
Does human ANF-(99-126) infusion improve diuresis and electrolyte excretion in patients with mild to moderate chronic renal failure?
In patients with mild to moderate chronic renal failure, plasma ANF is elevated and exogenous ANF infusion promotes diuresis, natriuresis, and blood pressure reduction.
Suda et al. (1988) studied this question.
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