Why the study?
Does low dose intravenous 99-126 atrial natriuretic factor infusion alter renal and hormonal parameters in patients with moderate to severe chronic renal failure not on dialysis?
Population
Mixed group of patients with moderate to severe chronic renal failure (CRF) not treated with dialysis
Comparison
Low dose intravenous 99-126 atrial natriuretic… vs Placebo
Design
Other
Authors
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May increase albuminuria in non-dialysis CRF despite natriuresis; leaves open net renal effects.
Does low dose intravenous 99-126 atrial natriuretic factor infusion alter renal and hormonal parameters in patients with moderate to severe chronic renal failure not on dialysis?
Low dose intravenous ANF infusion in non-dialysis CRF patients increases sodium excretion but also increases urinary albumin excretion, suggesting a potential detrimental effect on long-term renal function despite its role in sodium balance.
Woolf et al. (1989) studied this question.
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