Why the study?
What are the baseline levels of ANF and the physiological responses to ANF infusion in normal subjects compared to patients with congestive heart failure?
Population
Normal subjects and patients with congestive heart failure (CHF)
Comparison
Atrial natriuretic factor infusion of 0.10… vs Baseline values prior to infusion, and…
Design
Other
Authors
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Blunted ANF responsiveness in CHF suggests resistance; leaves open natriuretic augmentation strategies pending prospective validation.
What are the baseline levels of ANF and the physiological responses to ANF infusion in normal subjects compared to patients with congestive heart failure?
Patients with congestive heart failure have elevated baseline ANF levels but exhibit an attenuated renal and renin response to exogenous ANF infusion compared to normal subjects.
Cody et al. (1986) studied this question.
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