What question did this study set out to answer?

This research investigates the relationship between atrial natriuretic factor (ANF) levels and cardiac failure in models of left ventricular infarction and right ventricular pacing.

January 1, 1987Journal of Cardiovascular Pharmacology

Atrial Natriuretic Factor in Acute and Chronic Cardiac Failure

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This research investigates the relationship between atrial natriuretic factor (ANF) levels and cardiac failure in models of left ventricular infarction and right ventricular pacing.
Examined rats with left ventricular failure from infarction for plasma ANF levels and sodium, norepinephrine, and aldosterone excretion.
Studied six conscious dogs with induced heart failure to measure plasma ANF levels in different vascular locations during heart failure progression.
Increased plasma ANF levels correlate positively with infarction size and right atrial pressure.
A threefold increase in ANF levels was observed in dogs during heart failure; however, there was a 30% reduction in ANF in the renal vein compared to arteries.

Structured PICO

Population

Rats with left ventricular failure due to left ventricular infarction, and 6 conscious dogs with heart failure due to rapid right ventricular pacing.

Intervention

Measurement of plasma levels of atrial natriuretic factor (ANF) and related physiological parameters.

Comparator

Control values (for rats).

Outcome

Plasma levels of ANF and its correlation with hemodynamic parameters (infarct size, right atrial pressure, left ventricular end-diastolic pressure).surrogate

Plasma levels of ANF are significantly elevated in animal models of heart failure and correlate closely with right atrial pressure and infarct size.

Discussion

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Implication

ANF elevation may mark hemodynamic stress in experimental HF; leaves open its value as human biomarker or target.

Cite This Study

Riegger et al. (1987) studied this question.

synapsesocial.com/papers/6a710410e36a167817e2d8dc https://doi.org/10.1097/00005344-198700106-00022

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Atrial Natriuretic Factor in Acute and Chronic Cardiac Failure

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Atrial Natriuretic Factor in Acute and Chronic Cardiac Failure

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider