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September 1, 1989Circulation

Failure of atrial natriuretic factor to increase with volume expansion in acute and chronic congestive heart failure in the dog.

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Why the study?

Does acute saline volume expansion increase circulating ANF in dogs with acute and chronic congestive heart failure?

Population

17 dogs with congestive heart failure induced by rapid right ventricular pacing, divided into acute and…

Comparison

Acute saline volume expansion. vs Baseline and comparison between acute and…

Design

Preclinical

Authors

MRM. M. RedfieldMayo Clinic in ArizonaBEBrooks S. EdwardsUniversity of MinnesotaMMMichael D. McGoonVascular / Pulmonary Vascular

Discussion

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Implication

Attenuated ANF release in chronic CHF; hypothesis-generating for neurohormonal adaptation and leaves open human relevance.

Key Points

  • This study aims to determine the relationship between circulating ANF levels and atrial pressure in acute versus chronic congestive heart failure (CHF).
  • Measured cardiovascular hemodynamics and plasma ANF levels during acute and chronic CHF in dogs using right ventricular pacing.
  • Conducted acute saline volume expansion to observe the ANF response to increased atrial pressure.
  • Participants included 10 dogs for acute CHF and 7 dogs for chronic CHF.
  • In chronic CHF, right atrial pressure was significantly higher (8.5 +/- 0.9 mm Hg) than in acute CHF (3.4 +/- 1.3 mm Hg) with p < 0.05.
  • Circulating ANF levels were lower in chronic CHF (385 +/- 73 pg/ml) compared to acute CHF (500 +/- 89 pg/ml).
  • After volume expansion, right atrial pressure increased similarly in both groups, indicating diminished ANF response in chronic CHF.

Structured PICO

Does acute saline volume expansion increase circulating ANF in dogs with acute and chronic congestive heart failure?

P
Population
17 dogs with congestive heart failure (CHF) induced by rapid right ventricular pacing, divided into acute (n=10, 25 minutes pacing) and chronic (n=7, 14-16 days pacing) CHF models.
I
Intervention
Acute saline volume expansion.
C
Comparator
Baseline (before volume expansion) and comparison between acute and chronic CHF models.
O
Outcome
Changes in cardiovascular hemodynamics (right atrial pressure) and plasma levels of atrial natriuretic factor (ANF).surrogate

In a canine model, chronic congestive heart failure is associated with an attenuated release of atrial natriuretic factor despite elevated right atrial pressures.

Cite This Study

Redfield et al. (1989) studied this question.

synapsesocial.com/papers/6a7226cfa528af2d65c453d4https://doi.org/10.1161/01.cir.80.3.651

Topics

Heart failureHFrEF treatment
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Response of atrial natriuretic factor to acute and chronic increases of atrial pressures in experimental heart failure in dogs. Role of changes in heart rate, atrial dimension, and cardiac tissue concentration.1991 · 39 citations
  2. 2Increased ANF secretion after volume expansion is preserved in rats with heart failure1988 · 50 citations
  3. 3Atrial natriuretic factor, cardiac volumes and filling pressures during exercise in congestive heart failure1991 · 18 citations
  4. 4Atrial Natriuretic Factor in Acute and Chronic Cardiac Failure1987
  5. 5Atrial Natriuretic Factor in Acute and Chronic Cardiac Failure1987 · 6 citations