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March 1, 1991European Heart Journal

Atrial natriuretic factor, cardiac volumes and filling pressures during exercise in congestive heart failure

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Why the study?

How do cardiac volumes and filling pressures regulate atrial natriuretic factor (ANF) release at rest and during exercise in patients with congestive heart failure?

Population

6 male patients with congestive heart failure (CHF) and 13 normal male subjects

Comparison

Three graded exercise levels (E1, E2, E3) vs Rest conditions and normal male subjects

Design

Cohort

Authors

JDJulian DonckierCHU Dinant Godinne UCL NamurPCPatrick M. De CosterCHU Dinant Godinne UCL NamurJVJean‐Louis VanoverscheldeCardiac Imaging

Discussion

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Implication

ANF may reflect volumes and pressures in CHF; leaves open whether ANF modulation affects outcomes.

Structured PICO

How do cardiac volumes and filling pressures regulate atrial natriuretic factor (ANF) release at rest and during exercise in patients with congestive heart failure?

P
Population
6 male patients with congestive heart failure (CHF) and 13 normal male subjects
I
Intervention
Three graded exercise levels (E1, E2, E3)
C
Comparator
Rest conditions and normal male subjects
O
Outcome
Plasma atrial natriuretic factor (ANF) concentrations, cardiac volumes, and filling pressures at rest and during exercisesurrogate

In congestive heart failure, ANF release is regulated by cardiac volumes at rest and by left filling pressures during exercise.

Cite This Study

Donckier et al. (1991) studied this question.

synapsesocial.com/papers/6a843da4121b098de683e217https://doi.org/10.1093/oxfordjournals.eurheartj.a059898

Topics

HFrEF treatmentHeart failure
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Atrial Natriuretic Factor: Comparability of Venous and Arterial Plasma Measurements in Man at Rest and during Exercise1989 · 9 citations
  2. 2Exercise and Posture-Related Changes of Atrial Natriuretic Factor and Cardiac Function in Diabetes1989 · 9 citations
  3. 3Atrial natriuretic peptide: Evidence of action as a natriuretic hormone at physiological plasma concentrations in man1987 · 139 citations
  4. 4The plasma release of atrial natriuretic peptide in man1986 · 132 citations
  5. 5Effect of exercise on plasma atrial natriuretic factor and cardiac function in men and women1988 · 18 citations