Key result
In a canine model of pacing-induced heart failure, acute pacing and volume expansion increased plasma ANF, but by 1 week, ANF release was attenuated despite increased filling pressures.
Why the study?
Does acute right ventricular pacing and volume expansion increase plasma ANF concentration in a dog model of pacing-induced heart failure?
Population
43 dogs
Comparison
Acute right ventricular pacing, acute volume… vs Baseline state and normal control dogs
Design
Preclinical
Follow-up
Up to severe heart failure stage
Authors
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Attenuated ANF release may limit compensatory response in HF; leaves open whether this mechanism informs human therapies.
Does acute right ventricular pacing and volume expansion increase plasma ANF concentration in a dog model of pacing-induced heart failure?
p-value: p=<0.05
In a pacing-induced heart failure dog model, changes in heart rate, atrial pressure, and volume contribute to increased plasma ANF, though release is attenuated by 1 week.
Moe et al. (1991) studied Pacing-induced heart failure (n=43). Right ventricular pacing and volume expansion vs. Baseline and normal controls was evaluated on Plasma ANF concentration (p=<0.05). In a canine model of pacing-induced heart failure, acute pacing and volume expansion increased plasma ANF, but by 1 week, ANF release was attenuated despite increased filling pressures.
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