Key result
Increasing atrial rate to 250 or 300 min-1 in dogs significantly increased plasma-ANF (P<0.01), correlating with changes in atrial pressures and dimensions.
Why the study?
Does acute pacing tachycardia increase plasma-ANF levels through changes in atrial pressure and dimensions in dogs?
Population
8 anaesthetized dogs instrumented with atrial pressure catheters and sonomicrometers
Comparison
Pacing tachycardia with acute increase in atrial… vs Baseline or lower atrial rate (150 to 200 min-1)
Design
Preclinical
Follow-up
10 min per pacing stage
Authors
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Should not yet change clinical practice; leaves open translation of atrial ANF mechanisms to human arrhythmias.
Does acute pacing tachycardia increase plasma-ANF levels through changes in atrial pressure and dimensions in dogs?
p-value: p=<0.01
Acute atrial tachycardia increases plasma-ANF levels, which correlates with atrial dilatation and increased atrial pressures.
Riddervold et al. (1991) studied Acute supraventricular tachycardia (n=8). Pacing tachycardia vs. Atrial rate of 150 to 200 min-1 was evaluated on Plasma-ANF (p=<0.01). Increasing atrial rate to 250 or 300 min-1 in dogs significantly increased plasma-ANF (P<0.01), correlating with changes in atrial pressures and dimensions.
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