Population
Anesthetized dogs (n = 9)
Comparison
Right ventricular pacing (tachycardia) vs Control state (before and after pacing)
Design
Preclinical
Authors
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Animal data link sustained ANF to post-tachycardia natriuresis; leaves open relevance to human AF or HF.
Tachycardia-induced increases in ANF persist after pacing and may drive natriuresis once renal perfusion pressure is restored.
Miller et al. (1990) studied this question.
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