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February 1, 1988AJP Regulatory Integrative and Comparative Physiology

Increased ANF secretion after volume expansion is preserved in rats with heart failure

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Why the study?

Does acute blood volume expansion increase plasma ANF secretion in rats with chronic heart failure?

Population

Conscious rats with chronic heart failure induced by coronary artery ligation 3 weeks prior

Comparison

25% acute blood volume expansion vs Control rats without heart failure undergoing…

Design

Preclinical

Follow-up

5 minutes

Authors

YCYi‐Wen ChienTaipei Medical University HospitalRBR. Wayne BarbeeVirginia Commonwealth UniversityAMA. A. MacPheeTulane University

Discussion

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Implication

Preserved ANF response to volume expansion in this HF model; leaves open clinical relevance and challenges ANF deficiency assumptions.

Structured PICO

Does acute blood volume expansion increase plasma ANF secretion in rats with chronic heart failure?

P
Population
Conscious rats with chronic heart failure induced by coronary artery ligation 3 weeks prior
I
Intervention
25% acute blood volume expansion
C
Comparator
Control rats without heart failure undergoing the same volume expansion
O
Outcome
Change in plasma immunoreactive atrial natriuretic factor (ANF) level at 5 minutes after volume expansionsurrogate

In a rat model of heart failure, the capacity to increase plasma ANF secretion in response to acute volume expansion is preserved, indicating no relative deficiency of circulating ANF.

Cite This Study

Chien et al. (1988) studied this question.

synapsesocial.com/papers/6a797f1fe357fbdac58911e8https://doi.org/10.1152/ajpregu.1988.254.2.r185
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Atrial Natriuretic Factor in Acute and Chronic Cardiac Failure1987 · 6 citations
  2. 2Atrial Natriuretic Factor in Acute and Chronic Cardiac Failure1987
  3. 3Response of atrial natriuretic factor to acute and chronic increases of atrial pressures in experimental heart failure in dogs. Role of changes in heart rate, atrial dimension, and cardiac tissue concentration.1991 · 39 citations
  4. 4Failure of atrial natriuretic factor to increase with volume expansion in acute and chronic congestive heart failure in the dog.1989 · 56 citations
  5. 5Atrial natriuretic factor, cardiac volumes and filling pressures during exercise in congestive heart failure1991 · 18 citations