Key result
Patients with congestive heart failure (NYHA II/III) had a significantly higher ANP-Exercise Ratio (3.59) compared to normal subjects (0.96) and NYHA class I patients (1.32).
Why the study?
Does dynamic exercise elicit an augmented plasma atrial natriuretic peptide response in patients with congestive heart failure compared to normal subjects?
Observational (n=59)
Does dynamic exercise elicit an augmented plasma atrial natriuretic peptide response in patients with congestive heart failure compared to normal subjects?
Absolute Event Rate: 3.59% vs 0.96%
Patients with symptomatic congestive heart failure (NYHA II-III) demonstrate an augmented atrial natriuretic peptide response to dynamic exercise compared to normal subjects and asymptomatic patients.
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May support ANP-exercise ratio as marker of symptomatic HF severity; hypothesis-generating, requiring prospective validation before clinical use.
Kato et al. (1996) conducted an observational in Congestive heart failure (n=59). Congestive heart failure (NYHA II/III) vs. Normal subjects and NYHA class I patients was evaluated on ANP-Exercise Ratio [(peak ANP-rest ANP)/peak VO2]. Patients with congestive heart failure (NYHA II/III) had a significantly higher ANP-Exercise Ratio (3.59) compared to normal subjects (0.96) and NYHA class I patients (1.32).
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