Why the study?
Does chronic renal failure alter the secretion and plasma levels of atrial natriuretic factor in humans and rats?
Population
Rats with chronic renal failure induced by subtotal nephrectomy, and 6 patients with chronic renal failure…
Comparison
Subtotal nephrectomy; Haemodialysis vs Sham-operated controls (rats)
Design
Preclinical
Follow-up
1 week and 1 month (rats)
Authors
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May support compensatory ANF release in renal failure; leaves open any therapeutic role pending human trials.
Does chronic renal failure alter the secretion and plasma levels of atrial natriuretic factor in humans and rats?
Chronic renal failure increases the secretion of atrial natriuretic factor in both humans and rats, which is lowered by haemodialysis in humans.
Hodsman et al. (1987) studied this question.
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