Why the study?
Does hANP infusion affect blood pressure, PAC, and hANP metabolism differently in patients with chronic renal failure compared to normal volunteers?
Population
20 males, comprising 9 normal volunteers and 11 patients with chronic renal failure receiving hemodialysis.
Comparison
Synthetic alpha-human atrial natriuretic peptide… vs Normal volunteers receiving the same hANP…
Design
Other
Follow-up
40 minutes after initiating infusion
Authors
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Altered hANP clearance in CRF may require infusion caution; leaves open its hemodynamic impact in prospective studies.
Does hANP infusion affect blood pressure, PAC, and hANP metabolism differently in patients with chronic renal failure compared to normal volunteers?
The kidney plays an important role in the degradation of hANP, as evidenced by prolonged half-life and reduced metabolic clearance in patients with chronic renal failure.
Takagi et al. (1991) studied this question.
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