Why the study?
Does alpha-hANP infusion reduce plasma volume and what is its clearance in patients with end-stage renal failure?
Population
8 patients with end-stage renal failure and 6 normal volunteers (n=14)
Comparison
Synthetic atrial natriuretic peptide infused for… vs Vehicle (placebo) infused for 1 h
Design
RCT, random order on two separate occasions
Follow-up
1 hour
Authors
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ANP contracts plasma volume independently of renal function in ESRD; extends extrarenal mechanisms and supports nonrenal clearance.
Does alpha-hANP infusion reduce plasma volume and what is its clearance in patients with end-stage renal failure?
ANP promotes contraction of plasma volume via a mechanism independent of renal function, and its metabolism involves organs other than the kidney.
Tonolo et al. (1988) studied this question.
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