Key result
Low-dose adrenaline infusion significantly increased resting and stimulated levels of arterial and venous plasma noradrenaline, supporting adrenaline-facilitated noradrenaline release.
Why the study?
Does low-dose adrenaline infusion increase plasma noradrenaline levels in mild hypertensive and normotensive patients?
Does low-dose adrenaline infusion increase plasma noradrenaline levels in mild hypertensive and normotensive patients?
Physiological concentrations of adrenaline facilitate noradrenaline release in humans, independent of clearance mechanisms.
Answers are grounded in this paper and cite their sources.
Supports adrenaline-facilitated noradrenaline release at physiological levels; leaves open relevance to hypertension management pending higher-evidence trials.
Both resting and stimulated (straight-leg raising and head-up tilt) levels of arterial and venous plasma noradrenaline were significantly higher during low-dose adrenaline infusion in five mild hypertensive and four normotensive patients with one adrenal. Repeat adrenaline infusions in the five hypertensive patients while measuring noradrenaline clearance (3H-noradrenaline constant infusion) achieved similar levels of plasma adrenaline, and similar increases in plasma noradrenaline, within five min of achieving target infusion rate. Increased plasma noradrenaline was not explained by reduced clearance. These results are consistent with the hypothesis that physiological concentrations of adrenaline are capable of facilitating noradrenaline release in man.
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Musgrave et al. (1985) studied Mild hypertension and normotension (n=9). Low-dose adrenaline infusion was evaluated on Plasma noradrenaline levels. Low-dose adrenaline infusion significantly increased resting and stimulated levels of arterial and venous plasma noradrenaline, supporting adrenaline-facilitated noradrenaline release.
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