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April 1, 1986Journal of Hypertension

Stress Levels of Adrenaline Amplify the Blood Pressure Response to Sympathetic Stimulation

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Why the study?

Does adrenaline infusion amplify the blood pressure response to sympathetic stimulation in subjects with borderline hypertension?

Population

17 subjects with borderline hypertension

Comparison

Infusion of adrenaline, with or without a low… vs Saline infusion

Design

Other

Authors

HVH. H. VincentLeiden University Medical CenterFBFrans BoomsmaHeart Failure & TransplantAVArie J. Man ʼt VeldErasmus University Rotterdam

Discussion

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Implication

Suggests adrenaline amplifies sympathetic pressor responses in borderline hypertension; hypothesis-generating and should not yet change practice.

Key Points

  • To determine whether physiological stress levels of circulating adrenaline amplify sympathetic pressor responses by facilitating neuronal noradrenaline release.
  • Tested 17 subjects with borderline hypertension using standardized cold pressor and isometric exercise challenges.
  • Infused adrenaline to raise circulating plasma levels 8- to 9-fold compared to saline control infusions.
  • Administered low-dose propranolol during adrenaline infusion prior to the cold pressor test to assess receptor-mediated antagonism.
  • Adrenaline infusion augmented the rise in systolic and diastolic arterial pressure during cold pressor and isometric exercise tests, while heart rate responses remained unaltered.
  • Plasma noradrenaline levels were higher during adrenaline infusion both before and after sympathetic tests relative to saline, and this increase was fully antagonized by propranolol.

Structured PICO

Does adrenaline infusion amplify the blood pressure response to sympathetic stimulation in subjects with borderline hypertension?

P
Population
17 subjects with borderline hypertension
I
Intervention
Infusion of adrenaline (raising plasma adrenaline by a factor of 8 to 9), with or without a low dose of propranolol
C
Comparator
Saline infusion
O
Outcome
Rise in systolic and diastolic arterial pressure induced by standardized cold pressor and isometric exercise testssurrogate

Stress levels of circulating adrenaline amplify sympathetic pressor responses, likely by facilitating the release of neuronal noradrenaline.

Cite This Study

Vincent et al. (1986) studied this question.

synapsesocial.com/papers/6a880c878e586ad1c8a537cehttps://doi.org/10.1097/00004872-198604000-00018

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Elevated Plasma Adrenaline Reflects Sympathetic Overactivity and Enhanced α-Adrenoceptor-Mediated Vasoconstriction in Essential Hypertension1981 · 50 citations
  2. 2Circulating adrenaline and blood pressure: the metabolic effects and kinetics of infused adrenaline in man1980 · 51 citations
  3. 3Adrenaline infusion in man increases muscle sympathetic nerve activity and noradrenaline overflow to plasma1989 · 38 citations
  4. 4INCREASED PLASMA NORADRENALINE DURING LOW DOSE ADRENALINE INFUSION IN RESTING MAN AND DURING SYMPATHETIC STIMULATION1985 · 25 citations
  5. 5Adrenaline Responsiveness in Mild Hypertension: No Evidence for Altered β-Adrenoceptor Sensitivity1998 · 5 citations