What is the clinical evidence from this study?

Population: Experimental cardiogenic shock (n=10). Intervention: l-noradrenaline vs. Autologous transfusion. Primary outcome: Increase in left-ventricular stroke work in shocked animals.

What question did this study set out to answer?

To quantify and compare the inotropic effect of l-noradrenaline infusion in normal dogs versus dogs with experimentally induced cardiogenic shock.

January 1, 1965Canadian Journal of Physiology and Pharmacology

THE INOTROPIC EFFECT OF l-NORADRENALINE IN EXPERIMENTAL CARDIOGENIC SHOCK

View Full Paper

Ask AI

Bookmark

Key result

Noradrenaline infusion increased left-ventricular stroke work by 120% in dogs with cardiogenic shock, compared to a 35% increase with autologous transfusion, indicating an enhanced inotropic effect.

Why the study?

Does noradrenaline infusion improve left-ventricular stroke work compared to autologous transfusion in experimental cardiogenic shock?

Key Points

To quantify and compare the inotropic effect of l-noradrenaline infusion in normal dogs versus dogs with experimentally induced cardiogenic shock.
Studied 10 dogs divided into normal controls (N=5) and cardiogenic shock models (N=5) induced via closed-chest coronary embolization.
Administered noradrenaline infusion at 1 μg/kg/min and compared stroke work changes against autologous transfusion calibrated to equal mean left-atrial pressure rises.
Noradrenaline significantly increased arterial blood pressure, cardiac output, and mean left-atrial pressure in all animals, though cardiac output increases were significantly attenuated in shocked animals.
In control animals, noradrenaline increased left-ventricular stroke work by an average of 91% (for a 5.6 mm Hg left-atrial pressure rise) versus 72% with volume transfusion.
In shocked animals, noradrenaline increased left-ventricular stroke work by 120% compared to only 35% with transfusion at equivalent left-atrial pressure elevations.

Structured PICO

Does noradrenaline infusion improve left-ventricular stroke work compared to autologous transfusion in experimental cardiogenic shock?

Population

10 dogs (5 normal and 5 with experimental cardiogenic shock) evaluated for the hemodynamic effects of noradrenaline infusion.

Intervention

Noradrenaline infusion (1 μg/kg min)

Comparator

Autologous transfusion (elevating mean left-atrial pressure to the level attained during noradrenaline infusion)

Outcome

Inotropic effect (quantitated by comparing the increase in left-ventricular stroke work evoked by noradrenaline with the increase from autologous transfusion)surrogate

Main Result

Absolute Event Rate: 120% vs 35%

The inotropic effect of noradrenaline is significantly enhanced in experimental cardiogenic shock compared to normal controls.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Noradrenaline's amplified inotropy in shock models; leaves open clinical translation and human trial confirmation.

Cite This Study

Cronin et al. (1965) studied Experimental cardiogenic shock (n=10). l-noradrenaline vs. Autologous transfusion was evaluated on Increase in left-ventricular stroke work in shocked animals. Noradrenaline infusion increased left-ventricular stroke work by 120% in dogs with cardiogenic shock, compared to a 35% increase with autologous transfusion, indicating an enhanced inotropic effect.

synapsesocial.com/papers/6a97b6e56ac1408ff2e16fa5 https://doi.org/10.1139/y65-007

View Full Paper

Ask AI

Bookmark

THE INOTROPIC EFFECT OF l-NORADRENALINE IN EXPERIMENTAL CARDIOGENIC SHOCK

Key Points

Structured PICO

Main Result

Discussion

Implication

Cite This Study

THE INOTROPIC EFFECT OF l-NORADRENALINE IN EXPERIMENTAL CARDIOGENIC SHOCK

Key Points

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Also Consider

Also Consider