Key result
In experimental hemorrhagic hypotension in dogs, l-norepinephrine elicited significant increases in cardiac output and arterial pressure during early hemorrhage, but had no significant effect after the development of irreversible shock.
Why the study?
Does l-norepinephrine infusion improve cardiac output and arterial pressure in anesthetized dogs during graded hemorrhagic shock?
Population
18 fasting, mongrel dogs (mean weight 10.6 Kg) anesthetized with morphine tartrate, chloralose, and urethane.
Comparison
Intravenous l-norepinephrine infusion… vs Measurements taken immediately prior to…
Design
Preclinical
Follow-up
Acute experimental duration
Authors
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May support early but not irreversible hemorrhagic shock in dogs; leaves open clinical translation and vasopressor timing.
Does l-norepinephrine infusion improve cardiac output and arterial pressure in anesthetized dogs during graded hemorrhagic shock?
Absolute Event Rate: 1170% vs 804%
p-value: p=0.001
L-norepinephrine improves cardiac output and arterial pressure in early hemorrhagic shock but loses efficacy once irreversible shock develops, without significantly increasing total peripheral resistance.
Gilmore et al. (1954) studied Experimental hemorrhagic shock (n=18). l-norepinephrine vs. Pre-infusion baseline was evaluated on Cardiac output during early first stage of hemorrhage (p=0.001). In experimental hemorrhagic hypotension in dogs, l-norepinephrine elicited significant increases in cardiac output and arterial pressure during early hemorrhage, but had no significant effect after the development of irreversible shock.
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