Why the study?
Does norepinephrine augment cardiac output in normal and hypotensive anesthetized dogs?
Does norepinephrine augment cardiac output in normal and hypotensive anesthetized dogs?
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Norepinephrine does not appear to have a differential effect on cardiac output between normal and hypotensive anesthetized dogs.
It was the purpose of this investigation to test again the general conclusion that norepinephrine augments cardiac output during experimental hemorrhagic hypotension but has no such effect on normal animals or man. Results are presented which fail to support this differential action in normal and hypotensive dogs and an explanation is offered for failure of the drug to increase cardiac output in human subjects.
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Levy et al. (1957) studied this question.
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