What is the clinical evidence from this study?

Population: Hemorrhagic shock. Intervention: Norepinephrine infusion. Primary outcome: Survival or recovery.

What question did this study set out to answer?

To evaluate the impact of norepinephrine infusion on hemodynamics, regional blood flow, and survival in canine models of hemorrhagic shock before and after replacement transfusion.

July 1, 1956American Journal of Physiology-Legacy Content

Effect of Norepinephrine on Circulation of the Dog in Hemorrhagic Shock

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Key result

Norepinephrine infusion did not prolong survival or effect recovery of dogs in hemorrhagic shock unresponsive to replacement transfusion, despite increasing coronary, cerebral, and adrenal blood flow.

Why the study?

Does norepinephrine infusion improve survival or recovery in dogs in hemorrhagic shock?

Key Points

To evaluate the impact of norepinephrine infusion on hemodynamics, regional blood flow, and survival in canine models of hemorrhagic shock before and after replacement transfusion.
Administered norepinephrine infusions to canine models subjected to hemorrhagic shock before and after replacement blood transfusion.
Assessed survival outcomes, regional organ blood flow (coronary, cerebral, adrenal, renal, and hepatic), cardiac output, and intracardiac and pulmonary pressures.
Norepinephrine infusion failed to prolong survival or achieve recovery in dogs with hemorrhagic shock unresponsive to blood replacement.
Infusion increased coronary, cerebral, and adrenal blood flow, reduced renal blood flow, and produced no change in hepatic blood flow.
Cardiac output increased during the oligemic phase but not post-transfusion, while pulmonary arterial and auricular pressures increased and pulmonary vascular resistance decreased.

Structured PICO

Does norepinephrine infusion improve survival or recovery in dogs in hemorrhagic shock?

Population

Dogs in hemorrhagic shock unresponsive to replacement transfusion.

Intervention

Norepinephrine infusion

Outcome

Survival and recoveryhard clinical

In a canine model of hemorrhagic shock, norepinephrine alters regional hemodynamics but fails to improve survival.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Norepinephrine confers no survival benefit in this canine model despite regional flow gains; leaves open its role in other shock states or species.

Cite This Study

Frank et al. (1956) studied Hemorrhagic shock. Norepinephrine infusion was evaluated on Survival or recovery. Norepinephrine infusion did not prolong survival or effect recovery of dogs in hemorrhagic shock unresponsive to replacement transfusion, despite increasing coronary, cerebral, and adrenal blood flow.

synapsesocial.com/papers/6a97b6e66ac1408ff2e16fa7 https://doi.org/10.1152/ajplegacy.1956.186.1.74

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Implication

Norepinephrine confers no survival benefit in this canine model despite regional flow gains; leaves open its role in other shock states or species.

Effect of Norepinephrine on Circulation of the Dog in Hemorrhagic Shock

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Effect of Norepinephrine on Circulation of the Dog in Hemorrhagic Shock

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider