Key result
In a canine model of systemic hypotension complicating pulmonary hypertension, both norepinephrine and methoxamine increased mean blood pressure to ~121 mmHg (P<0.001), but only norepinephrine increased cardiac output.
Why the study?
Does norepinephrine or methoxamine improve cardiac output in a canine model of systemic hypotension complicating acute pulmonary hypertension?
Population
13 anesthetized ventilated dogs with systemic hypotension complicating an acute increase in pulmonary…
Comparison
Sequential infusion of norepinephrine and… vs Comparison between the two drugs and baseline
Design
Preclinical
Authors
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May support norepinephrine over pure vasopressors for output in this canine model; leaves open translation to human pulmonary hypertension.
Does norepinephrine or methoxamine improve cardiac output in a canine model of systemic hypotension complicating acute pulmonary hypertension?
p-value: p=<0.001
Norepinephrine, but not methoxamine, improves cardiac output in a canine model of acute pulmonary hypertension with systemic hypotension, likely due to its direct inotropic effect.
Ducas et al. (1995) studied Systemic hypotension complicating pulmonary hypertension (n=13). Norepinephrine and Methoxamine vs. Baseline was evaluated on Mean blood pressure and cardiac output (p=<0.001). In a canine model of systemic hypotension complicating pulmonary hypertension, both norepinephrine and methoxamine increased mean blood pressure to ~121 mmHg (P<0.001), but only norepinephrine increased cardiac output.
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